There are quite a few people at SXSW right now who are tweeting endlessly about stuff that gives me major butt hurt, so I'm inclined to unfollow them.
But then I have to remember to follow them again, once SXSW is over, and they regain their perspective (i.e. not everything is about SXSW). I know I won't remember.
Also while you're at it, give us a command to delete a single tweet. That can't be very hard. I don't want to delete it everywhere, just in my @connect tab. That way when someone says something they probably shouldn't have said, rather than be reminded of it over and over, I can just remove it from sight. Been waiting for this feature for years.