Until late last year (2013, Happy New Year) when I needed to write a little utility script that would do a housekeeping task on the net for me, I would write it in Frontier.
The most useful utilities so far have acted as a bridge between RSS and Twitter. It's how my linkblogging tool connects with it now. And it is still relying on a server for the final step.
My old friend Jeff Sandquist, who used to be the lead developer guy at Microsoft, is now doing that at Twitter. I keep telling Jeff I have no interest in doing anything on top of Twitter, but then I keep doing things on top of Twitter. Oy! Yes, they could make it better. I shouldn't need a proxy to talk to their server. My desktop JS should be able to talk directly to their server.
Where do I think this will go? Well, there's no question you could write a full RSS aggregator to run on the desktop in the browser, even on a tablet or a phone. Decentralization is now much much easier than it ever has been, and it's coming at a good time, with all the michegas from the NSA.